New resolution mathematical model could solve century’s scientific myths about sildenafil and tadalafil

Uncovering an 18,000-word mathematical model of a single protein at a time has been a daunting task for the laboratories of Prof. Sun Hongzhui at the National University of Singapore (NUS). The researchers put this new challenge to the test by working with a quantum group of 8,000 scientists for a study entitled ‘A simpler model with higher efficiency'.

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The findings have been published in the scientific journal Nature Communications on 20 February 2020. ‘On a difficult routine task,’ Sun says, ‘we applied the best strategies of our best scientific colleagues'. The team worked diligently and thought out a 50-layer mathematical model for a pathway protein containing a novel mechanism in which it is chemically altered. ‘With the help of NUS scientists and with a lot of effort, we managed to solve this incredibly complex task', says the expert.

Engrossing in the task of enriching data.

Understanding protein kinetics Understanding protein kinetics is called the ‘PCK math problem'. It is a common scientific problem that towers over scientists although it is often overlooked in mainstream science. Mostly, it comes to the point where researchers investigate proteins in concentrations ranging from a few nanometres to trillions. In this way, they need to tease out the genetics, the chemistry, and the chemistry associated with proteins. ‘In this new challenge, we used the full array of computational approaches whereby we went deep into the calculations and set out to net whole, instead of trying to answer one or two protein kinetics questions at a time', says the top-ranked Singaporean scientist, PhD student Christina Ng.