Researchers have discovered that vitamin D (the sunshine compound) in small droplets released by the skin after over-the-counter topical treatments may help reduce the severity of respiratory disturbances and help better patients manage the pain of chronic cold-causing bronchitis.
This research, led by Cornell University's Marina Wiedenheft, director of the School of Public Health Research Training Program, and senior author on the paper is published in the journal Nature Microbiology.
"Unfortunately, vitamin D supplementation often ends in a worsening of respiratory symptoms and increasing the amount of ruffled, itchy, runny or itchy, itchy, stuffed, or itchy skin," Wiedenheft said. "Vitamin D seems to be an effective therapy for chronic respiratory ailments, but when we're trying to fight chronic respiratory illnesses, vitamin D doesn't seem to help."
She said that Wiedenheft and her colleagues were looking at levels of two estrogen metabolites—progesterone and estrogenic alpha-1,3-diol—in peripheral sweat, and the increased amounts of these metabolites—increasing by 117 percent and 172 percent percent, respectively—in the blood, after using Gel-8 monotherapy with melatonin, a phototherapeutic made by the participants.
For the study, Wiedenheft and her colleagues were looking at levels of faecal leukotrienes (FLEs)—an estrogenic alkyl component—in the blood, after using T-Style infrared laser therapy, which is similar to T-Blast in appearance, frequency, mode of operation, and cost.
Wiedenheft said that combining the use of treatment with UV irradiation and T-Style light therapy could improve the effectiveness and safety of T-Style for the treatment of chronic bronchitis and respiratory discomfort. "We know that a drop in FLE levels is seen in patients after treatment," she said.
"In this study, we're doing an assessment of vitamin D in the droplets shortly after topical treatment, and then use a test that measures FLE levels immediately after treatment," she said. "That's when we can potentially determine how much vitamin D is available in the skin, as it's a good indication of vitamin D levels in the blood."
Wiedenheft said that in patients with infectious diseases, vitamin D was found to be decreased without treatment, and when vitamin D levels in excreted sweat doubled, vitamin D decreased. "That's a good indication that vitamin D is an effective bronchostatic intervention, and we can start to figure out what role vitamin D might play in treating chronic bronchitis."
The study, "Measurement and analysis of serum, urinary, and endothelial FLE concentrations in patients with chronic universal or chronic common androgenic asthma treated with melatonin mixed with lavender oil: a randomised controlled trial", was conducted by Nicola Wiedenheft, Kireet Banerjee, Raed Zuraie, and Paul Regan, with support from the National Institute for Health Research and Collett Foundation and funded by NIHR.